New paper out in Open biology

The recent work of graduate student Adam Hockenberry and Research Assistant Professor Adam Pah is now online. This work is a part of a multi-year collaboration with Professor Michael Jewett investigating the mechanisms by which the sequence of messenger-RNA molecules alters translation rates. In this particular work, we focus on novel genome-scale measurements of translation efficiencies and show strong support for a long-standing model where ribosome binding strength to upstream regions significantly alters the translation efficiency of downstream genes. Intriguingly, we show that both weak and strong binding interactions result in decreased translation efficiency.