We just published a new paper performing a large-scale investigation of the reasons why potentially important genes are ignored.
T Stoeger, M Gerlach, RI Morimoto, LAN Amaral
Large-scale investigation of the reasons why potentially important genes are ignored
PLOS Biology (2018)
We find that several mechanisms have led to an ossification in the research about human genes. This leaves large gaps in our understanding of biology.
A non-technical summary can be found at Northwestern News
Some news coverage:
New York Times by Carl Zimmer
Atlantic by Ed Yong